Peak Mind Recovery – Post Session Formula

The Peak Mind Recovery formula is designed to replenish energy reserves and metabolic needs by providing essential vitamins and regenerative precursors for neurons. It also helps mitigate the side effects of MDMA and helps post-session recovery.

Journey work pushes both the mind and body to their limits. Substances like MDMA triggers a massive release of neurotransmitters, a highly energy-demanding process that can alter brain chemistry over time. This surge leads to changes in receptor density, neuron connections, and, in some cases, neuronal loss. These effects require significant metabolic energy, depleting the brain’s reserves and contributing to fatigue, cognitive fog, and recovery challenges after use. While some neurons adapt by modifying their surface receptors, repeated exposure can result in long-term structural changes.

The B vitamins play a critical role in recovery and regeneration. They promote energy production and are directly involved in brain cell functions, metabolism, and regeneration [2, 3].

Vitamin B1 or thiamine is involved in energy production from food (carbohydrates and glucose), the chief energy supply for brain cells. It also plays a role in nerve regeneration by reducing hyperexcitability caused by excessive neurotransmitter secretion by MDMA.

Vitamin B2, also known as riboflavin, is required for proper functioning of enzymes in the neurons. It is crucial for working and recycling other B vitamins, such as vitamin B3, vitamin B6, and folic acid, and transporting oxygen inside the cell.

Vitamin B3 or Niacin is involved in maintaining metabolic activity. Most of the neurons' enzymatic and biochemical activities depend on vitamin B3 or its derivatives, including NAD (nicotinamide adenine dinucleotide) or NAD phosphate.

Besides enzymatic reactions, vitamin B3 controls cellular signaling by modulating calcium and folate ions. Vitamin B3 can bind to niacin receptor 1 (NIACR1) in brain cells.

Vitamin B6, or Pyridoxine, produces neurotransmitters, including dopamine, serotonin, γ-aminobutyric acid (GABA), norepinephrine, and melatonin. It can limit the release of glutamate from MDMA-mediated hyperexcited neurons to limit neuronal damage. It can restore the sensory nerve function of stressed neurons. Additionally, it can contribute to the synthesis of sphingolipids that constitute the protective coating around neurons.

Vitamin B12 regulates nerve regeneration and recovery. It helps regulate neurotrophic factors (proteins or peptides that promote neuron growth, survival, and maintenance). It also encourages the myelination of neurons. Myelin is a sheath of phospholipids around some neurons that provides nutrition and protection to neurons. Vitamin B12 is food for neurons and fuel for biochemical activities in the nervous system.

Vitamin D3 is critical in neuron growth, maintenance, and modulation. It regulates the activity of microglia cells in the nervous system. Microglia cells are housekeeping cells that remove noxious chemicals from the brain tissues, thus protecting the neurons from toxic chemicals and waste metabolites.

Vitamin D3 promotes the production of nerve growth factor (NGF), which stimulates neuron growth, the development of new neurons from brain stem cells, and the differentiation of developing neurons into mature neurons. This effect is pronounced for dopaminergic (dopamine-producing) neurons [4].

Vitamin D also controls the activity of neurotransmitters at synapses (neuron junctions). As most of the action of MDMA happens at synapses, it can be under physiological stress after taking MDMA. Vitamin D regulates the enzymes and proteins involved in the housekeeping of synapses [5].

One of the effects of MDMA is the massive release of serotonin. As this effect fades after an MDMA dose, it leads to a sudden drop of serotonin in the brain tissues, which produces characteristic symptoms of anxiety and depression (drop-phase). Inositol can substitute for serotonin and mimic its effects by binding to 5-HT2 (5-hydroxytryptamine) receptors. Its effects can mimic mild serotonin selective reuptake inhibitors (SSRIs) to counter the sudden drop in serotonin levels. Several clinical studies reported these effects of inositol [6]. Peak Mind Formula contains 750 mg of myo-inositol per sachet to counter the drop-phase of MDMA.

N-acetyl-L-Carnitine can cross the blood-brain barrier and improve energy metabolism in brain cells, regulate neurotransmitter production, and help neurons adapt to changing neural networks (neural plasticity) under MDMA effects. It has been proven effective in treating depression and anxiety, which can help mitigate MDMA drop-phase after an active session [7]. It also has a role in synthesizing acetylcholine and its release into the brain tissues.

Phenylpiracetam and Noopept are piracetam-derived compounds with nootropic effects, i.e., increased tolerance to the extreme impacts of MDMA (or other factors), neuroprotective effects, improved blood circulation in the brain, and reduced anxiety and stress [7].

Phenylpiracetam in Peak Mind Recovery can improve dopamine and acetylcholine release, increase the density of dopamine neurons, and improve brain sensitivity to dopamine. As dopamine is the primary neurotransmitter involved in mood enhancement and motivation, phenylpiracetam can counter the depressive effects of MDMA drop-phase.

Noopept, on the other hand, has neuroprotective properties to ensure long-term cognitive health. It has been reported to enhance the production of brain-derived neurotrophic factor (BDNF), a protein involved in regulating secretions of neurotransmitters, establishing neural connections in the brain, and improving signal transmission among the neurons.

Vitamin C is an essential antioxidant for brain cells. It is also considered a neuromodulator (works with neurotransmitters to transmit or inhibit signals) for dopamine, acetylcholine, serotonin, and GABA neurons [8].

Suggested Intake

It is recommended to continue taking Peak Mind Recovery for 7 days or more after taking MDMA for optimal results.

Precautions!

This product can increase wakefulness and should be taken early in the day to avoid sleep disruptions.

This product may interact with seizure medications. If you have pre-existing health conditions, consult a health professional before taking this product.

References

1. Mustafa NS, Bakar NH, Mohamad N, Adnan LH, Fauzi NF, Thoarlim A, Omar SH, Hamzah MS, Yusoff Z, Jufri M, Ahmad R. MDMA and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicity. Basic and clinical neuroscience. 2020 Jul;11(4):381.
2. Baltrusch S. The role of neurotropic B vitamins in nerve regeneration. BioMed Research International. 2021;2021(1):9968228.
3. Kennedy DO. B vitamins and the brain: mechanisms, dose, and efficacy—a review. Nutrients. 2016 Feb;8(2):68.
4.  Cui X, Eyles DW. Vitamin D and the central nervous system: Causative and preventative mechanisms in brain disorders. Nutrients. 2022 Oct 17;14(20):4353.
5.  Shi Y, Shi Y, Jie R, He J, Luo Z, Li J. Vitamin D: The crucial neuroprotective factor for nerve cells. Neuroscience. 2024 Sep 27.
6.  Levine J, Mishori A, Susnosky M, Martin M, Belmaker RH. Combination of inositol and serotonin reuptake inhibitors in the treatment of depression. Biological psychiatry. 1999 Feb 1;45(3):270-3.
7.  Voronina TA. Cognitive impairment and nootropic drugs: Mechanism of action and spectrum of effects. Neurochemical Journal. 2023 Jun;17(2):180-8.
8. Harrison FE, May JM. Vitamin C function in the brain: the vital role of the ascorbate transporter SVCT2. Free Radical Biology and Medicine. 2009 Mar 15;46(6):719-30.

* The % daily value is based on the 2,000 calories diet.

** Dietary value is not established.